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Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

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Published on: December 27, 2024

Canine pododermatitis and idiopathic disease.

Rory M Breathnach1, Shay Fanning, Grace Mulcahy

  • 1School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland. rory.breathnach@ucd.ie

Veterinary Journal (London, England : 1997)
|October 9, 2007
PubMed
Summary

Pododermatitis is an inflammatory skin disease in dogs. Lymphocytic-plasmacytic pododermatitis, a specific type, shows characteristic histopathology and responds well to immunomodulatory therapy.

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Published on: February 9, 2024

Area of Science:

  • Veterinary Dermatology
  • Canine Pathology

Background:

  • Pododermatitis is a frequent inflammatory skin condition in dogs.
  • Diagnosing the cause of pedal lesions can be challenging, often leading to an "idiopathic" diagnosis.
  • Idiopathic pododermatitis represents a small percentage of dermatology referrals.

Purpose of the Study:

  • To describe a specific subgroup of idiopathic pododermatitis.
  • To highlight the histopathological features and clinical presentation of this subgroup.
  • To evaluate treatment responses in affected dogs.

Main Methods:

  • Histopathological examination of pedal lesions.
  • Clinical assessment of affected dogs, including pruritus, erythema, swelling, pain, and alopecia.
  • Evaluation of treatment outcomes with antimicrobial, antiparasitic, elimination diets, and immunomodulatory therapies.

Main Results:

  • A subgroup of idiopathic pododermatitis is characterized by epidermal hyperplasia, hyperkeratosis, spongiosis, dermal edema, and perivascular lymphocytic-plasmacytic aggregates.
  • Affected dogs exhibit clinical signs of pedal inflammation and discomfort.
  • These cases are unresponsive to conventional therapies but show positive responses to immunomodulatory treatment.

Conclusions:

  • Lymphocytic-plasmacytic pododermatitis (LPP) is a distinct histopathological pattern within idiopathic pododermatitis.
  • LPP in dogs requires immunomodulatory therapy for effective management.
  • Further research into the pathogenesis of LPP is warranted.