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Impairment of recognition memory in interleukin-6 knock-out mice
Anna Hryniewicz1, Izabela Bialuk, Karol A Kamiński
1Department of General and Experimental Pathology Medical University of Bialystok Mickiewicza 2c, 15-222 Bialystok, Poland. annah@amb.edu.pl
European Journal of Pharmacology
|October 9, 2007
Abstract:
We have used transgenic male mice not expressing interleukin-6 (IL-6) [C57BL/6J(IL-6/-tm Kopf)] in object recognition test to assess the role of endogenous IL-6 in recognition memory. Wild-type controls showed better memory than IL-6 knock-out mice. Results of our experiment suggest that endogenous IL-6 may play an important role in the process of recognition memory in mice.
