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Brief and long maternal separations decrease corticosterone secretion in a lupus-prone strain: dissociation from

Bruna Catallani1, Beatriz Duarte Palma, Frida Zaladek Gil

  • 1Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, 925, 04024-002 Vila Clementino, São Paulo, SP, Brazil.

Brain, Behavior, and Immunity
|October 9, 2007
PubMed
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Neonatal maternal separation in mice did not alter lupus development but reduced corticosterone (CORT) levels. These separations also disrupted the link between CORT, immune activity, and lifespan in NZB/NZWF1 female mice.

Area of Science:

  • Neuroimmunology
  • Endocrinology
  • Autoimmune disease research

Background:

  • Neonatal stress impacts the immune system and hypothalamus-pituitary-adrenal (HPA) axis.
  • Maternal separation is a common model to study early-life stress effects.
  • NZB/NZWF1 mice are a model for studying lupus pathogenesis.

Purpose of the Study:

  • To investigate if brief and long maternal separations (BMS, LMS) affect murine lupus onset and progression in NZB/NZWF1 females.
  • To determine the association between corticosterone (CORT) secretion patterns and lupus development.
  • To assess the impact of neonatal stress on the relationship between glucocorticoids and immune function.

Main Methods:

  • Daily maternal separation (15 min for BMS, 3 hours for LMS) during postnatal days 1-14.

Related Experiment Videos

  • Monitoring of anti-nuclear antibodies (ANA) and anti-double-strand DNA (anti-dsDNA) antibodies from week 9 to 34.
  • Measurement of serum corticosterone (CORT) levels and urine collection throughout the study period.

    • Main Results:

    • No significant differences in lupus-related parameters between BMS, LMS, and non-manipulated (NM) groups.
    • LMS group showed a trend towards later onset of anti-dsDNA antibodies.
    • BMS and LMS mice exhibited lower CORT levels compared to NM mice.
    • Neonatal manipulations abolished the correlation between CORT levels and ANA onset/lifespan observed in NM mice.

    Conclusions:

    • Neonatal maternal separation in NZB/NZWF1 mice does not alter lupus progression but significantly reduces corticosterone levels.
    • Early-life stress modifies basal CORT secretion and disconnects the association between glucocorticoids and immune activity.
    • The findings highlight the long-term neuroendocrine and immunomodulatory effects of neonatal stress.