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Related Experiment Video

Updated: Jul 11, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Multiple vertebral osteonecrosis.

Rose-Marie Javier¹, Thomas Moser, Jean-Louis Dietemann

¹Department of Rheumatology, Hôpital de Hautepierre, 67000 Strasbourg, France. rose-marie.javier@chru-strasbourg.fr

Joint Bone Spine

|October 9, 2007

Summary

Vertebral osteonecrosis, a condition affecting the spine, can present with a double-line sign on MRIs, even without vertebral collapse. This finding challenges previous understandings of vertebral clefts and osteonecrosis.

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Last Updated: Jul 11, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Area of Science:

Radiology
Orthopedic Surgery
Pathology

Background:

Vertebral osteonecrosis is often associated with intravertebral vacuum clefts, typically seen in older patients with severe fractures and instability.
These clefts were historically considered pathognomonic for vertebral osteonecrosis but are now viewed as indicators of fracture non-union.

Observation:

The double-line sign, classically associated with long bone osteonecrosis, has rarely been reported in the spine.
This case presents a histologically confirmed multilevel vertebral osteonecrosis exhibiting a double-line sign.

Findings:

The vertebral osteonecrosis manifested as a double-line sign.
This occurred in the absence of vertebral collapse and was unrelated to radiotherapy.

Implications:

The double-line sign may be a more versatile imaging biomarker for vertebral osteonecrosis than previously thought.
This finding expands the differential diagnosis for the double-line sign in spinal imaging.