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Related Experiment Video

Updated: Jul 11, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Inflammasomes and rheumatic diseases: evolving concepts.

P I Sidiropoulos¹, G Goulielmos, G K Voloudakis

¹Department of Rheumatology, Clinical Immunology and Allergy, University Hospital, Medical School, University of Crete, Heraklion, Greece. sidiropp@med.uoc.gr

Annals of the Rheumatic Diseases

|October 9, 2007

Summary

This summary is machine-generated.

Innate immunity, specifically nucleotide-binding and oligomerisation domain (NOD)-like receptors (NLRs) and inflammasomes, plays a key role in inflammatory rheumatic diseases. Targeting these pathways offers potential therapeutic strategies for conditions like rheumatoid arthritis and gout.

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Area of Science:

Immunology
Rheumatology
Molecular Biology

Background:

Inflammatory rheumatic diseases involve cytokine production triggered by endogenous signals.
Innate immunity mechanisms are increasingly recognized for their role in disease pathogenesis.
Nucleotide-binding and oligomerisation domain (NOD)-like receptors (NLRs) are key sensors in innate immunity.

Purpose of the Study:

To explore the role of NLRs and inflammasomes in the pathogenesis of inflammatory rheumatic diseases.
To understand how NLRs contribute to the initiation and progression of inflammation in rheumatic conditions.
To identify inflammasome pathways as potential therapeutic targets.

Main Methods:

Review of recent data on NLRs and inflammasome complexes.
Analysis of inflammasome components: NLR sensor, ASC adaptor, and caspase effector.
Investigation of inflammasome activation leading to pro-inflammatory cytokine release (IL-1β, IL-18).

Main Results:

NLRs are implicated in sensing cellular damage and endogenous metabolites.
Inflammasomes, comprising NLRs, ASC, and caspases, activate key inflammatory cytokines.
Evidence suggests inflammasome involvement in autoinflammatory and rheumatic diseases like rheumatoid arthritis and gout.

Conclusions:

The inflammasome pathway is a significant contributor to the pathogenesis of inflammatory rheumatic diseases.
Targeting NLRs and inflammasome signaling presents a promising therapeutic avenue.
Further research into these innate immunity pathways could lead to novel treatments for rheumatic conditions.