Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.

Peter J Coffey1, Carlos Gias, Caroline J McDermott

  • 1Division of Cellular Therapy, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|October 9, 2007
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England)·2026
Same author

Robust and reproducible population receptive field mapping in patients with retinal pathologies.

Eye (London, England)·2026
Same author

Computed tomography assessment after out-of-hospital cardiac arrest resuscitation.

Resuscitation plus·2026
Same author

A novel CEP78 variant and rod-cone dystrophy in non-consanguineous siblings.

Ophthalmic genetics·2026
Same author

Leveraging the shared and opposing genetic mechanisms in the heritable cardiomyopathies.

Research square·2026
Same author

A Dual-Fusogenic Virus-like Vector Enables Direct Cytosolic Delivery of mRNA Vaccines to Dendritic Cells.

ACS nano·2026
Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles
This summary is machine-generated.

Complement factor H (CFH) is essential for retinal health. CFH deficiency in mice led to vision loss and retinal structural damage, highlighting its critical role in preventing age-related macular degeneration.

Area of Science:

  • Ophthalmology
  • Immunology
  • Genetics

Background:

  • Age-related macular degeneration (AMD) is a leading cause of blindness.
  • Genetic variations in complement factor H (CFH) are linked to AMD susceptibility.

Purpose of the Study:

  • To investigate the role of CFH in retinal health and disease.
  • To analyze the functional and anatomical consequences of CFH deficiency in a mouse model.

Main Methods:

  • Functional analysis using electroretinography to assess visual acuity and rod response.
  • Anatomical analysis via confocal scanning laser ophthalmoscopy and tissue section examination.
  • Utilized CFH-deficient (cfh(-/-)) mice and age-matched controls.

Main Results:

Related Experiment Videos

  • CFH-deficient mice showed significantly reduced visual acuity and rod function.
  • Increased autofluorescent subretinal deposits were observed in cfh(-/-) mice.
  • Accumulation of complement C3, Bruch's membrane thinning, and photoreceptor disorganization were noted in deficient mice.

Conclusions:

  • CFH is crucial for maintaining long-term retinal function.
  • CFH deficiency leads to retinal pathology even without external immune challenges.
  • This study underscores the importance of CFH in preventing retinal degeneration.