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Related Concept Videos

Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

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Related Experiment Video

Updated: Jul 11, 2026

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Patch testing experience with 1000 patients.

A K Bajaj1, Abir Saraswat, Gaurav Mukhija

  • 1bajajak1945@yahoo.co.in

Indian Journal of Dermatology, Venereology and Leprology
|October 9, 2007
PubMed
Summary
This summary is machine-generated.

This study analyzed 1000 patients in North India, finding footwear and medicament dermatitis common. Nickel and potassium dichromate were frequent allergens, highlighting the need for updated patch testing series.

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A Protocol of Manual Tests to Measure Sensation and Pain in Humans
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Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
06:31

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A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

Area of Science:

  • Dermatology
  • Allergology
  • Epidemiology

Background:

  • Patch testing is crucial for diagnosing allergic contact dermatitis (ACD).
  • Understanding contact sensitization trends is vital for developing standard testing series.
  • There is a lack of extensive patch testing data from India.

Purpose of the Study:

  • To present nine-year patch test data from a North Indian dermatology center.
  • To identify common allergens and patterns of allergic contact dermatitis in the region.

Main Methods:

  • 1000 consecutive patients with suspected ACD were patch tested between May 1997 and April 2006.
  • The Indian Standard Series was used, with additions of Parthenium, cetrimide, and chloroxylenol for selected patients.

Main Results:

  • 59% of patients (590/1000) showed positive reactions.
  • Footwear dermatitis was the most common suspected diagnosis, followed by medicament, cosmetic, and plant dermatitis.
  • Nickel (12.9%), potassium dichromate (11.1%), and Parthenium (14.5% of those tested) were significant allergens. Men showed higher potassium dichromate sensitivity, while women showed higher nickel sensitivity.

Conclusions:

  • The study indicates a higher prevalence of footwear and medicament dermatitis than previously reported in India.
  • Allergies to antiseptics are notably significant in the studied population.
  • Collaborative, multi-center studies are necessary to establish a comprehensive understanding of ACD prevalence across India.