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Response of central nervous system aspergillosis to voriconazole

Prakash Balasubramaniam1, Pranesh B Madakira, Anish Ninan

  • 1Department of Neurology, PSG Institute of Medical Sciences and Research, Avinasi Road, Peelamedu, Coimbatore - 641 002, India.

Neurology India
|October 9, 2007
PubMed

Insights

This case study highlights voriconazole

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Fungal infections of the central nervous system (CNS) often manifest as subacute meningitis.
  • Aspergillosis can present as brain abscess or granuloma, with CSF analysis showing neutrophils.

Observation:

  • A 69-year-old diabetic male with CNS aspergilloma invading from the para-nasal sinus was treated with voriconazole.
  • The patient experienced relapse of subacute meningitis symptoms upon self-discontinuation of voriconazole due to cost.
  • Restarting voriconazole led to clinical improvement.

Findings:

  • Voriconazole demonstrated clinical efficacy in treating CNS aspergillosis.
  • The case provides evidence for the antifungal activity of voriconazole against invasive aspergillosis.

Implications:

  • Voriconazole is a viable oral treatment option for CNS aspergillosis.
  • Treatment adherence is crucial for managing invasive fungal infections of the CNS.

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