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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Current understanding of heart failure with preserved ejection fraction
1Advanced Herat Disease Section, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02445, USA. adesai@partners.org
Current Opinion in Cardiology
|October 9, 2007
Summary
Heart failure with preserved ejection fraction (HFpEF) presents a growing challenge with limited treatment options. While extracardiac factors are implicated, current therapies remain empiric, focusing on symptom management rather than mortality reduction.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) affects a significant patient population, carrying a substantial burden of morbidity and mortality.
- Understanding the pathophysiology of HFpEF remains incomplete, with limited evidence-based therapeutic strategies available.
Purpose of the Study:
- To review the current understanding of HFpEF, including its epidemiology, pathophysiology, and therapeutic options.
- To highlight the increasing prevalence and poor prognosis of HFpEF despite existing medical therapies.
Main Methods:
- Review of recent findings on HFpEF, including epidemiological data and results from randomized controlled trials.
- Analysis of the role of diastolic dysfunction and extracardiac factors in HFpEF progression.
Main Results:
- The prevalence of HFpEF is rising, and patient outcomes remain poor.
- Extracardiac factors like renal dysfunction and aortic stiffness are increasingly recognized as important contributors to HFpEF.
- Renin-angiotensin system blockade may reduce morbidity, but no strategy currently reduces mortality in HFpEF.
Conclusions:
- Consensus on HFpEF pathophysiology and optimal treatment is lacking.
- Current treatment for HFpEF is largely empiric, focusing on blood pressure control, rhythm management, and diuresis.
- Further therapeutic trials are needed to establish evidence-based strategies for improving HFpEF outcomes.
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