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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

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Updated: Jul 11, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

Urinary bladder leiomyosarcoma in adults.

Apostolos P Labanaris1, Vahudin Zugor, Bernd Meyer

  • 1Department of Urology, Martha Maria Medical Center, Stadenstrasse 58, 90409 Nurnberg, Germany. Labanaris@web.de

International Urology and Nephrology
|October 9, 2007
PubMed
Summary

Bladder leiomyosarcomas, rare aggressive tumors, can be successfully treated with aggressive surgical resection. Complete tumor removal with wide margins leads to favorable outcomes and low recurrence rates.

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Area of Science:

  • Urology
  • Surgical Oncology
  • Pathology

Background:

  • Non-urothelial bladder neoplasms are rare, comprising less than 5% of all bladder tumors.
  • Bladder leiomyosarcomas are the most common mesenchymal malignancy of the bladder in adults.

Purpose of the Study:

  • To investigate the clinicopathologic presentation and outcomes of bladder leiomyosarcomas.
  • To evaluate the efficacy of aggressive surgical management for these rare tumors.

Main Methods:

  • Retrospective review of seven patients with bladder leiomyosarcomas treated between 2000 and 2007.
  • Initial diagnosis via transurethral resection, followed by definitive surgical procedures.

Main Results:

  • Seven patients (5 male, 2 female; median age 64.8 years) underwent complete surgical resection with negative margins (100%).
  • Most patients (86%) presented with high-grade tumors and advanced stage (MSKCC stage 3).

Conclusions:

  • Bladder leiomyosarcomas, though aggressive, may have a better prognosis than previously thought.
  • Aggressive surgical extirpation, including radical cystectomy with wide margins, is crucial for successful treatment.
  • Adherence to surgical techniques resulted in low rates of positive margins and local recurrence.