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Updated: Jul 11, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi's sarcoma after liver transplantation
Fabrizio Di Benedetto1, Stefano Di Sandro, Nicola De Ruvo
1Liver and Multivisceral Transplant Center, University of Modena and Reggio Emilia, Via del Pozzo, 71-41100 Modena, Italy. f.diben@virgilio.it
Journal of Cancer Research and Clinical Oncology
|October 9, 2007
Summary
Kaposi
Area of Science:
- Oncology
- Transplantation Immunology
- Virology
Background:
- Kaposi's Sarcoma (KS) is a rare cancer linked to HHV8 infection.
- Standard KS treatment guidelines for immunosuppressed patients are lacking.
- Six cases of KS were observed post-liver transplantation (LT) at our center.
Purpose of the Study:
- To investigate the incidence and management of Kaposi's Sarcoma in liver transplant recipients.
- To evaluate treatment outcomes for KS in this patient population.
Main Methods:
- Retrospective analysis of six liver transplant recipients who developed KS.
- Patients received immunosuppressive regimens including calcineurin inhibitors and steroids or daclizumab.
- HHV8 detection via serology pre-LT and PCR post-KS diagnosis.
Main Results:
- KS developed a mean of 6.2 months post-LT.
- Common underlying conditions included HBV-related cirrhosis and HCC.
- Treatment involved doxorubicin or switching to sirolimus, with some patients experiencing regression, while others expired.
Conclusions:
- KS in LT recipients requires a multidisciplinary approach for early diagnosis and management.
- Reducing immunosuppression or switching to sirolimus can induce KS regression.
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