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Related Experiment Video

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic pustular folliculitis.

Wajiha Sufyan¹, Kong-Bing Tan, Soon-Tee Wong

¹Department of Pathology, National University Hospital, Singapore 119074, Singapore.

Archives of Pathology & Laboratory Medicine

|October 10, 2007

Summary

This summary is machine-generated.

Ofuji's disease, a chronic skin condition primarily affecting East Asians, presents as facial plaques with eosinophilic inflammation. Its exact cause remains unknown, but immune system involvement is suspected.

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Last Updated: Jul 11, 2026

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Published on: May 10, 2024

Area of Science:

Dermatology
Immunology

Background:

Classical eosinophilic pustular folliculitis, also known as Ofuji's disease, is a relapsing skin condition.
It predominantly affects East Asian populations, typically manifesting on the face.

Purpose of the Study:

To summarize the clinical and histopathological characteristics of Ofuji's disease.
To highlight the diagnostic challenges and potential associations of this dermatosis.

Main Methods:

Review of clinical presentations.
Analysis of histopathological findings, focusing on dermal eosinophilic infiltrate and microabscesses.
Consideration of differential diagnoses and associated conditions.

Main Results:

Ofuji's disease begins as papules that form plaques, primarily on the face.
Histopathology shows prominent eosinophilic infiltrate around pilosebaceous units, sometimes with microabscesses.
Differential diagnosis is challenging and requires clinicopathologic correlation. Associations with HIV, drugs, and lymphomas exist.

Conclusions:

Ofuji's disease is a distinct dermatosis with characteristic clinicopathologic features.
Accurate diagnosis requires careful evaluation to differentiate it from other eosinophilic skin conditions.
While the etiology is unknown, immune processes are strongly implicated in its pathogenesis.