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Peroxisome proliferator-activated receptor-gamma ligands as investigational modulators of angiogenesis

Costas Giaginis1, Alexandra Margeli, Stamatios Theocharis

  • 1University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75 M. Asias Street, Goudi, GR11527, Athens, Greece.

Expert Opinion on Investigational Drugs
|October 10, 2007
PubMed

Insights

Peroxisome proliferator-activated receptor gamma (PPAR-gamma) ligands show promise in treating metabolic disorders and cancer. This review highlights their role in regulating angiogenesis for various diseases.

Area of Science:

  • Pharmacology and Molecular Biology
  • Oncology
  • Endocrinology

Background:

  • PPAR-gamma ligands are approved insulin sensitizers for metabolic disorders.
  • These ligands exhibit pleiotropic effects on cell proliferation, impacting cancer research.
  • Angiogenesis is crucial in tumor development and diabetic complications.

Purpose of the Study:

  • To review the role of PPAR-gamma ligands in angiogenesis.
  • To explore their therapeutic potential in malignant and non-malignant conditions.

Main Methods:

  • Literature review of preclinical and in vivo studies.
  • Analysis of data on PPAR-gamma ligands and angiogenesis modulation.

Main Results:

  • PPAR-gamma ligands demonstrate significant roles as angiogenesis modulators.
  • Evidence supports their function in both cancer and diabetes-related angiogenesis.

Conclusions:

  • PPAR-gamma is a potential therapeutic target for diseases involving excessive angiogenesis.
  • This includes cancer and complications associated with diabetes.

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