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Published on: June 18, 2020
Biomarker discovery in human SLE nephritis
Brad H Rovin1, Daniel J Birmingham, Haikady N Nagaraja
1Division of Nephrology, Ohio State University College of Medicine, and Columbus Children's Hospital Research Center 43210, USA. Rovin.1@osu.edu
Bulletin of the NYU Hospital for Joint Diseases
|October 10, 2007
Summary
Predicting systemic lupus erythematosus (SLE) nephritis flares could improve patient outcomes. This review explores using urine biomarkers to develop prediction models for SLE nephritis, aiming to reduce treatment complications.
Area of Science:
- Nephrology
- Immunology
- Biomarker Discovery
Background:
- Systemic lupus erythematosus (SLE) nephritis treatment carries risks.
- Predicting renal flare onset, severity, and response is crucial for managing SLE nephritis.
- Current treatment strategies for SLE nephritis can lead to significant morbidity and mortality.
Purpose of the Study:
- To discuss an approach for deriving prediction equations for SLE nephritis flare.
- To highlight the importance of identifying biomarkers for lupus nephritis.
- To explore the potential of urine as a source for SLE nephritis biomarkers.
Main Methods:
- Review of approaches to derive prediction equations for SLE nephritis flare.
- Identification of biomarkers for lupus nephritis.
- Analysis of urine biomarker discovery studies using candidate and proteomic methods.
Main Results:
- Urine is a viable source for identifying SLE nephritis biomarkers.
- Candidate and proteomic approaches have been used in urine biomarker discovery for SLE nephritis.
- The development of prediction equations requires robust biomarker identification.
Conclusions:
- Predictive models for SLE nephritis flare can potentially mitigate treatment-related side effects.
- Biomarker discovery in urine is key to developing accurate prediction equations.
- Further research into urine biomarkers could personalize SLE nephritis management.
