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Related Experiment Video

Updated: Jul 11, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Caudate structural abnormalities in idiopathic normal pressure hydrocephalus.

E E DeVito¹, C H Salmond, B K Owler

¹Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Acta Neurologica Scandinavica

|October 10, 2007

Summary

Idiopathic normal pressure hydrocephalus (iNPH) is linked to reduced caudate nucleus volume. This finding may explain cognitive and affective changes in iNPH patients.

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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

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Published on: March 28, 2025

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Last Updated: Jul 11, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

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Published on: May 19, 2015

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Area of Science:

Neurology
Neuroimaging
Neuroanatomy

Background:

Idiopathic normal pressure hydrocephalus (iNPH) is a form of reversible dementia.
Patients with iNPH often exhibit fronto-striatal cognitive deficits and apathy.

Purpose of the Study:

To investigate structural volumetric changes in the brain of iNPH patients.
To identify brain regions affected in iNPH beyond ventriculomegaly.

Main Methods:

Employed voxel-based morphometry for full-brain analysis.
Compared 11 iNPH patients with 14 healthy controls.
Conducted manual volumetric analyses on identified regions of interest (ROIs).

Main Results:

Diminished caudate nuclei volume was observed in the iNPH group.
Analyses included measurements of the caudate nucleus and corpus callosum.

Conclusions:

The caudate nucleus volume reduction is a significant finding in iNPH.
Further research should explore the caudate nucleus's role in iNPH-related cognitive and affective symptoms.