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Updated: Jul 11, 2026
Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
Published on: November 20, 2015
[Study of intracerebral focus changes on CADASIL by using MR imaging]
Jian-ce Li1, De-xin Jin, Yun-jun Yang
1Department of Radiology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Magnetic resonance imaging reveals progressive white matter lesions and new infarcts in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients over three years.
Area of Science:
- Neurology
- Neuroimaging
- Genetics
Context:
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cerebrovascular disorder.
- Understanding the dynamic progression of brain lesions is crucial for managing CADASIL.
Purpose:
- To investigate the dynamic changes in intracerebral lesions in patients with CADASIL using magnetic resonance (MR) imaging.
- To analyze lesion distribution, size, and shape over a three-year period.
Summary:
- Retrospective analysis of 7 CADASIL patients revealed increased white matter lesion volume and number in most patients.
- New lacunar infarcts appeared in 5 patients, and some lesions became confluent.
- MR imaging demonstrated the progression of brain abnormalities in CADASIL.
Impact:
- MR imaging provides insights into the dynamic evolution of brain lesions in CADASIL.
- This study aids in understanding disease progression and prognosis for CADASIL patients.
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