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Updated: Jul 11, 2026
10:22
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Immediate hypersensitivity and delayed hypersensitivity to clopidogrel.
D Gutiérrez-Fernández1, M S Fuentes-Vallejo, M D Rueda-Ygueravides
1Servicio de Neumología-Alergia, Hospital Puerta del Mar, Cádiz, Spain. drgutierrez@comcadiz.com
Allergologia Et Immunopathologia
|October 10, 2007
Summary
Clopidogrel hypersensitivity can manifest as immediate or delayed reactions. This study identifies Type 1 and delayed hypersensitivity mechanisms in two patients, aiding in understanding adverse drug reactions.
Area of Science:
- Immunology
- Pharmacology
- Clinical Medicine
Background:
- Clopidogrel is an antiplatelet medication used for secondary prevention of atherosclerotic events.
- Clinical manifestations of clopidogrel hypersensitivity include urticaria, skin rash, and angioedema.
- The immunological mechanisms underlying clopidogrel hypersensitivity are not fully established.
Observation:
- Two cases of hypersensitivity reactions to clopidogrel are presented.
- The first case involved an immediate reaction confirmed as Type 1 hypersensitivity via cutaneous testing.
- The second case presented a delayed hypersensitivity reaction, verified by oral challenge testing.
Findings:
- The study demonstrates distinct immunological mechanisms for clopidogrel hypersensitivity.
- Type 1 hypersensitivity was identified in an immediate reaction.
- Delayed hypersensitivity was confirmed in a separate case.
Implications:
- Understanding the immunological basis of clopidogrel hypersensitivity is crucial for patient management.
- Distinguishing between immediate and delayed reactions aids in diagnosis and treatment.
- Demonstrated tolerance to ticlopidine in the delayed reaction suggests potential alternative antiplatelet options.
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