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Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Videos

Gastrointestinal bleeding in older adults.

Syed H Tariq1, George Mekhjian

  • 1Division of Geriatric Medicine, Department of internal medicine, St. Louis University School of Medicine, Room M-238, 1402 South Grand, St. Louis, MO 63104, USA. tariqsh@slu.edu

Clinics in Geriatric Medicine
|October 10, 2007
PubMed
Summary

Gastrointestinal bleeding is common in older adults, often complicated by comorbidities and medications. This review covers the presentation, causes, diagnosis, and management of GI bleeding in the elderly.

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Area of Science:

  • Gastroenterology
  • Geriatric Medicine

Background:

  • Gastrointestinal (GI) bleeding is a significant cause of hospitalization in elderly patients.
  • Comorbidities and polypharmacy in older adults complicate clinical outcomes and management decisions.
  • Diagnostic and therapeutic approaches for GI bleeding in the elderly are often influenced by resource availability and local expertise.

Purpose of the Study:

  • To provide a comprehensive overview of gastrointestinal bleeding in older adults.
  • To discuss the clinical presentation, etiology, diagnostic strategies, and treatment options for elderly patients with GI bleeding.

Main Methods:

  • This article is a review of current literature and clinical practice regarding gastrointestinal bleeding in the elderly.
  • It synthesizes information on the unique aspects of GI bleeding in this demographic.

Main Results:

  • The article details the common presentations and diverse etiologies of upper and lower GI bleeding in older individuals.
  • It highlights the challenges in diagnosis and treatment due to age-related physiological changes and comorbidities.

Conclusions:

  • Effective management of gastrointestinal bleeding in older adults requires a tailored approach considering their specific health status and available resources.
  • Understanding the nuances of GI bleeding in the elderly is crucial for optimizing patient outcomes.