Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classification of carcinogens: polemics, pedantics, or progress?

D B Clayson1, D J Clegg

  • 1Bureau of Chemical Safety, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario.

Regulatory Toxicology and Pharmacology : RTP
|October 1, 1991
PubMed
Summary

Some rodent carcinogens cause cancer through mechanisms not applicable to humans. Regulatory approaches must differentiate between genotoxic and non-genotoxic carcinogens, recognizing species-specific effects for accurate risk assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue.

Scientific reports·2017
Same author

Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass.

Endocrinology·2016
Same author

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption.

International journal of obesity (2005)·2015
Same author

Estrogen, astrocytes and the neuroendocrine control of metabolism.

Reviews in endocrine & metabolic disorders·2013
Same author

Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.

Acta physiologica (Oxford, England)·2011

Area of Science:

  • Toxicology
  • Carcinogenesis
  • Risk Assessment

Background:

  • Rodent carcinogens exhibit diverse mechanisms of action, with varying relevance to human health.
  • Current regulatory strategies for carcinogen risk assessment may not be universally applicable, particularly for non-genotoxic agents.

Purpose of the Study:

  • To review mechanisms of rodent carcinogenesis and their human relevance.
  • To highlight the limitations of current regulatory approaches for certain carcinogens.
  • To advocate for the acceptance of species-specific carcinogen effects.

Main Methods:

  • Review of scientific literature on rodent carcinogen mechanisms.
  • Analysis of high-dose toxicity, homeostasis, unphysiological conditions, and cellular proliferation.

Related Experiment Videos

  • Examination of regulatory approaches to carcinogen risk assessment.

    • Main Results:

    • Non-genotoxic carcinogens can act through mechanisms (e.g., high-dose toxicity, induced proliferation) that are species-specific.
    • The maximum tolerated dose concept may lead to unphysiological conditions and misinterpretation of rodent carcinogen data.
    • Some rodent carcinogens likely do not pose a risk to humans due to species-specific biological differences.

    Conclusions:

    • A critical need exists for regulatory agencies to acknowledge and accept that some carcinogens are species-specific.
    • Differentiating between genotoxic and non-genotoxic carcinogens is crucial for accurate human health risk assessment.
    • Public and regulatory acceptance of species-specific carcinogen effects is essential for meaningful carcinogen regulation.