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Updated: Jul 11, 2026

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

Published on: July 6, 2015

[Correlation study between cadaverine level in saliva and halitosis].

Wei Ye¹, Yun-wu Li, Xi-ping Feng

¹Department of Preventive and Pediatric Dentistry, College of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.

Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology

|October 10, 2007

Summary

High-performance liquid chromatography (HPLC) can determine cadaverine levels in saliva, correlating with halitosis. This method aids in the clinical diagnosis of bad breath.

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Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

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Published on: March 1, 2024

Area of Science:

Analytical Chemistry
Biochemistry

Context:

Halitosis is a common condition with significant psychosocial impact.
Current diagnostic methods for halitosis rely heavily on subjective organoleptic assessments.
Biogenic amines, such as cadaverine, are implicated in the volatile compounds contributing to oral malodor.

Purpose:

To establish a robust high-performance liquid chromatography (HPLC) method for quantifying cadaverine in human saliva.
To investigate the correlation between salivary cadaverine concentrations and the severity of halitosis as assessed by organoleptic testing.

Summary:

A validated HPLC method was developed using 1,6-hexanediamine as an internal standard, with a mobile phase of methanol and a buffered aqueous solution (water:phosphoric acid:triethylamine).
Detection was performed at 231 nm, demonstrating linearity (R²=0.9985) over a 5-80 nmol/ml range with good recovery (91.5%) and precision (RSD 6.93%).
A statistically significant positive correlation (P<0.01) was observed between salivary cadaverine levels and organoleptic test scores for halitosis.

Impact:

The developed HPLC method provides an objective and reliable tool for measuring salivary cadaverine.
Findings suggest that cadaverine quantification can serve as a valuable biomarker for the clinical diagnosis and assessment of halitosis.
This objective measurement may complement subjective organoleptic evaluations, leading to more accurate halitosis diagnosis.