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A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
Published on: May 6, 2016
Diffuse leptomeningeal seeding from benign choroid plexus papilloma.
M Ortega-Martínez1, J M Cabezudo-Artero, I Fernández-Portales
1Services of Neurosurgery, Hospital Regional Universitario Infanta Cristina, Avda de Elvas s/n, Badajoz, Spain. marta.ort@terra.es
Acta Neurochirurgica
|October 10, 2007
Summary
Choroid plexus papillomas (CPPs), typically benign, can rarely disseminate within the cerebrospinal fluid. This case highlights an unusual instance of diffuse leptomeningeal seeding from a benign fourth ventricle CPP.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Choroid plexus papillomas (CPPs) are rare intracranial tumors originating from the choroid plexus epithelium.
- These tumors are generally considered benign with a good prognosis after surgical resection.
- While local recurrence is possible, leptomeningeal dissemination is exceptionally rare.
Observation:
- This report details an unusual case of a fourth ventricle choroid plexus papilloma.
- The tumor exhibited diffuse leptomeningeal seeding.
- Neither the primary tumor nor its recurrence displayed malignant histological features.
Findings:
- The patient's choroid plexus papilloma demonstrated an atypical pattern of widespread leptomeningeal spread.
- Despite the benign histology, the tumor was refractory to systemic and intrathecal chemotherapy.
- This case underscores the potential for aggressive behavior in histologically benign CPPs.
Implications:
- This case challenges the conventional understanding of benign choroid plexus papillomas.
- It highlights the need for vigilance regarding potential leptomeningeal dissemination, even with non-malignant histology.
- Further research into the mechanisms and management of CPP leptomeningeal spread is warranted.
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