Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbiome-behavior coupling shapes infant adaptation to early maternal unpredictability.

Frontiers in microbiology·2026
Same author

The potential of low-field MRI for global dementia care.

Nature reviews. Neurology·2026
Same author

Increased Brain-Age Gap in Young Adults With Psychotic Experiences.

Biological psychiatry global open science·2026
Same author

Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI.

Communications biology·2026
Same author

Diffusion Tensor MRI and Spherical-Deconvolution-Based Tractography on an Ultra-Low Field Portable MRI System.

Human brain mapping·2026
Same author

Motion-compensated spin-echo cardiac diffusion tensor imaging in multiple cardiac phases using an ultrahigh gradient strength scanner.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026

Related Experiment Video

Updated: Jul 11, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

A longitudinal study of diffusion tensor MRI in ALS.

Camilla R V Blain1, Victoria C Williams, Clare Johnston

  • 1King's College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, Department of Clinical Neuroscience, UK.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
|October 10, 2007
PubMed
Summary

Diffusion tensor imaging (DTI) detects corticospinal tract damage in amyotrophic lateral sclerosis (ALS). However, diffusion measures did not significantly change over time, suggesting limitations for tracking disease progression with current DTI methods.

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Related Experiment Videos

Last Updated: Jul 11, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

  • Neuroimaging
  • Neurology
  • Biomarker Research

Background:

  • Amyotrophic lateral sclerosis (ALS) involves progressive neurodegeneration.
  • Corticospinal tract integrity is compromised in ALS.
  • Diffusion tensor MRI (DTI) is a potential tool for assessing white matter changes.

Purpose of the Study:

  • To determine if DTI can detect progressive corticospinal tract degeneration in ALS.
  • To assess if diffusion variables correlate with clinical deterioration in ALS patients.
  • To evaluate DTI's utility as a biomarker for ALS progression.

Main Methods:

  • Whole-brain DTI scans were performed on 23 ALS patients and 25 healthy controls.
  • A subset of participants underwent a second scan for longitudinal assessment.
  • Region of interest analysis was used to measure fractional anisotropy (FA) and mean diffusivity (MD) in the corticospinal tract.

Main Results:

  • Significant differences in FA and MD were observed between ALS patients and controls at both time points.
  • No significant longitudinal changes in FA or MD were detected in ALS patients over time.
  • Clinical measures of disease severity increased in ALS patients during the study period.

Conclusions:

  • DTI can detect corticospinal tract damage in ALS patients.
  • Current DTI analysis methods may not be sensitive enough to track longitudinal changes in ALS.
  • High dropout rates suggest MRI may be limited to early-stage ALS biomarker research.