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Related Experiment Video

Updated: Jul 11, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Published on: August 18, 2020

Increased anterior cingulate cortex volume in bipolar I disorder.

Ali Javadapour1, Gin S Malhi, Belinda Ivanovski

  • 1Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia.

The Australian and New Zealand Journal of Psychiatry
|October 10, 2007
PubMed
Summary

Bipolar disorder (BD) patients show a larger right anterior cingulate cortex (ACC) volume, suggesting early volumetric changes. This increased ACC size may reflect its role in managing affective instability in early-stage BD.

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Published on: November 27, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Anterior cingulate cortex (ACC) involvement in bipolar disorder (BD) pathophysiology is suggested by functional neuroimaging.
  • Volumetric studies of ACC in BD have yielded inconsistent findings.
  • Previous studies often lacked clinical robustness in subject characterization.

Purpose of the Study:

  • To investigate volumetric abnormalities in the ACC of individuals with BD.
  • To address methodological inconsistencies and clinical robustness issues in prior research.
  • To compare ACC volumes between well-matched BD patients and control subjects.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to compare ACC volumes.
  • 24 BD patients were matched with 24 healthy controls on gender, age, and education.
  • Findings were analyzed in relation to illness and treatment factors.

Main Results:

  • A significantly larger (26%) right ACC volume was observed in BD patients compared to controls.
  • This ACC volume difference was independent of psychosis history, familiality, or lithium treatment.
  • Larger ACC volumes correlated with fewer affective episodes, indicating early-stage changes.

Conclusions:

  • Increased ACC size has implications for the neurobiology of BD.
  • Greater ACC mediation may be necessary for controlling affective instability in early BD.
  • The enlarged ACC likely reflects its role in conflict resolution during the early course of the illness.