[Current aspects of Paget's bone disease].

Area of Science:

• Bone biology and pathology
• Rheumatology
• Epidemiology

Context:

• Paget's disease of bone is a well-characterized chronic skeletal disorder.
• It involves heightened osteoclast and osteoblast activity, leading to abnormal bone remodeling.
• Understanding its geographical distribution and etiology is crucial.

Purpose:

• To review recent advancements in understanding Paget's disease of bone.
• To explore epidemiological data, particularly geographical variations.
• To investigate potential etiological factors, including a viral hypothesis.
• To summarize current therapeutic strategies.

Summary:

• Paget's disease of bone is marked by excessive bone turnover.
• Epidemiological studies reveal distinct geographical patterns.
• Evidence suggests a possible viral etiology, supported by advanced molecular techniques.
• Effective treatments, including calcitonin and bisphosphonates, are available.

Impact:

• Provides a comprehensive overview of Paget's disease of bone.
• Highlights key areas of research, including etiology and epidemiology.
• Informs clinicians about current and emerging treatment options.
• Contributes to a better understanding of this complex skeletal disorder.