Related Experiment Video
Updated: Jul 11, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
[Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels]
Yan-ting Wu1, Xiu-e Lu, Ting-ting Wang
1The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Objective:
To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation.
Methods:
Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group.
Result:
BMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01).
Conclusion:
Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.
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