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Updated: Jul 11, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
Freezing imine exchange in dynamic combinatorial libraries with Ugi reactions: versatile access to templated
Ludger A Wessjohann1, Daniel G Rivera, Fredy León
1Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, Halle/Saale, Germany. wessjohann@ipb-halle.de
Abstract:
A novel approach to freeze the imine exchange process in dynamic combinatorial libraries by Ugi reactions was developed. Macrocyclic oligoimine libraries previously formed and altered by addition of metal templates are efficiently quenched by multiple multicomponent reactions. The approach may be considered as an alternative to the typical reduction with borohydrides and delivers polyazamacrocycles with variable side arms. High dilution is not required to achieve high yields.
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