Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimal protocol selection for cardiopulmonary exercise testing in severe COPD.

Roberto P Benzo1, Sriram Paramesh, Sanjay A Patel

  • 1Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Suite 1211 Kaufmann Building, 3471 Fifth Ave, Pittsburgh, PA 15213, USA. benzorp@upmc.edu

Chest
|October 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Transplant Go (LTGO): A Randomized Controlled Trial to Evaluate the Efficacy of a Telerehabilitation Behavioral Exercise Intervention after Lung Transplantation.

International journal of telerehabilitation·2026
Same author

Home-Based Rehabilitation With Health Coaching for Rural Patients Living With COPD: A Sub-Analysis of a Randomized Trial.

Chest·2026
Same author

Respiratory mortality per STAR, GOLD, and ERS/ATS COPD severity classification.

Annals of the American Thoracic Society·2026
Same author

Wearable Sleep Measures May Improve Machine Learning Prediction of Home-Based Pulmonary Rehabilitation Engagement Among Patients With Chronic Obstructive Pulmonary Disease: A Proof-of-Concept Study.

Mayo Clinic proceedings. Digital health·2026
Same author

Medication adherence in thoracic transplant candidates.

Frontiers in psychology·2026
Same author

Clinical and economic impact of vascular access teams utilizing an IC-ECG-based tip confirmation system for peripherally inserted central catheters.

Expert review of medical devices·2026
Same journal

Wearable-derived activity and physiological changes following pleural intervention in malignant pleural effusion.

Chest·2026
Same journal

The effect of a two-day stay at high altitude (2500 m) on right ventricular afterload and oxygen delivery in patients with pulmonary vascular disease A randomized controlled crossover trial.

Chest·2026
Same journal

A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

Chest·2026
Same journal

Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

Chest·2026
Same journal

Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

Chest·2026
Same journal

Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

Chest·2026
See all related articles

For severe COPD patients, cardiopulmonary exercise testing (CPET) should be 5-9 minutes, not 8-12 minutes. This duration better reflects peak oxygen consumption (VO2peak) in this population.

Area of Science:

  • Pulmonary Medicine
  • Exercise Physiology

Background:

  • Current cardiopulmonary exercise testing (CPET) duration recommendations (8-12 min) are based on healthy individuals.
  • These recommendations may not be optimal for achieving peak oxygen consumption (VO2peak) in patients with severe Chronic Obstructive Pulmonary Disease (COPD).

Purpose of the Study:

  • To determine the optimal duration for CPET to achieve VO2peak in patients with severe COPD.
  • To compare different workload protocols for their effectiveness in this patient group.

Main Methods:

  • Eleven patients with severe COPD (mean FEV1 32%) underwent four symptom-limited incremental exercise tests.
  • Tests included 4, 8, and 16 W/min continuous ramp protocols and an 8 W/min step protocol on a cycle ergometer.
  • A randomized double-blind design was employed.

Related Experiment Videos

Main Results:

  • The mean test duration across all protocols was 6.3 minutes.
  • Test durations varied significantly by protocol, ranging from 4.0 min (16-W ramp) to 8.7 min (4-W ramp).
  • Maximal workload increased with higher ramp rates (p<0.001), but VO2peak, heart rate, and Borg ratings did not differ significantly across protocols.

Conclusions:

  • A CPET duration of 5-9 minutes is more appropriate for severe COPD patients (GOLD stages III-IV) than the current 8-12 minute guideline.
  • Maximal workload achieved during CPET is sensitive to the ramp incrementation rate, unlike VO2peak.