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CD14+ monocyte levels in subgroups of acute coronary syndromes
Ibrahim Ozdogru1, Mehmet Tugrul Inanc, Namk Kemal Eryol
1Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr
Insights
Percentages of CD14(+) monocytes differed significantly among acute coronary syndrome (ACS) subgroups. CD14(+) monocyte levels may help distinguish unstable angina from myocardial infarction in ACS patients.
Area of Science:
- Immunology
- Cardiology
- Biomarkers
Background:
- CD14(+) monocytes are key innate immune cells implicated in atherosclerosis.
- Understanding monocyte dynamics is crucial for diagnosing and managing acute coronary syndromes (ACS).
Purpose of the Study:
- To investigate differences in CD14(+) monocyte percentages across ACS subgroups: unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI).
Main Methods:
- Enrolled 115 ACS patients (24 UA, 29 NSTEMI, 62 STEMI).
- Measured C-reactive protein levels and CD14(+) monocyte percentages on admission.
- Utilized analysis of variance and Bonferroni posthoc tests for statistical analysis.
Main Results:
- Significant differences in CD14(+) monocyte percentages were found between ACS groups (P=0.013).
- UA group showed significantly lower CD14(+) monocyte percentages compared to NSTEMI (P=0.014) and STEMI (P=0.049) groups.
- C-reactive protein levels were significantly lower in the UA group than in NSTEMI and STEMI groups (P<0.002).
Conclusions:
- CD14(+) monocyte percentages vary significantly between ACS subgroups.
- CD14(+) monocyte levels serve as a potential biomarker for differentiating UA from myocardial infarction within ACS.
Objectives:
We aimed to investigate whether there were any differences in the percentages of CD14(+) monocytes between subgroups of acute coronary syndromes (ACS). CD14(+) is a monocyte surface receptor that plays a role in the innate immune system. CD14(+) monocytes are associated with complications of atherosclerosis.
Methods:
In total we enrolled 115 patients with ACS: 24 with unstable angina (UA); 29 with non-ST elevation myocardial infarction (NSTEMI); and 62 with ST elevation myocardial infarction (STEMI). The levels of C-reactive protein and percentage of CD14(+) monocyte were measured on admission.
Results:
CD14(+) monocyte percentages were observed to be different between groups by analysis of variance test. The percentages of CD14(+) monocyte were 81.24+/-10.04% in the UA group; 89.40+/-5.84% in the NSTEMI group; and 87.22+/-11.75% in the STEMI group (P=0.013). The differences between the UA and the NSTEMI and between the UA and the STEMI groups with Bonferroni posthoc testing were significant (P=0.014 and P=0.049 respectively). Moreover, no significant difference was found between the NSTEMI and STEMI groups (P=1.000). The C-reactive protein levels in the UA group were detected to be significantly low with Bonferroni posthoc testing compared with both the NSTEMI and STEMI groups (for both comparisons, P<0.002).
Conclusions:
A significant difference in CD14(+) monocyte percentages between subgroups of ACS was determined. CD14(+) monocyte percentages can be a useful parameter in differentiating between the subgroups of ACS, especially between UA and myocardial infarction.
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