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Growth hormone and developmental ocular function: clinical and basic studies.

Stephen Harvey1, Marie-Laure Baudet, Esmond J Sanders

  • 1Department of Physiology, 7-55 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada. steve.harvey@ualberta.ca

Pediatric Endocrinology Reviews : PER
|October 11, 2007
PubMed
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Growth hormone (GH) is vital for postnatal growth and plays a role in eye development. Understanding GH

Area of Science:

  • Ophthalmology and Endocrinology
  • Growth Hormone Research
  • Ocular Development Biology

Background:

  • Growth hormone (GH) is essential for postnatal growth.
  • The eye is a known target for GH, with potential endocrine, autocrine, and paracrine functions.
  • Ocular abnormalities are observed in conditions of GH deficiency or excess, suggesting a role in eye development.

Purpose of the Study:

  • To review the current understanding of growth hormone's role in ocular development.
  • To consolidate evidence from clinical and basic research on GH's impact on eye growth and function.
  • To highlight the significance of GH in maintaining normal ocular development.

Main Methods:

  • Review of clinical case studies involving pituitary GH disorders.

Related Experiment Videos

  • Analysis of basic science research investigating GH signaling pathways in ocular tissues.
  • Synthesis of existing literature on GH's effects on eye development and function.

    • Main Results:

    • Evidence supports GH's involvement in ocular development beyond its role in general growth.
    • GH influences ocular tissues through various mechanisms, including endocrine, autocrine, and paracrine actions.
    • Disruptions in GH levels are linked to specific ocular abnormalities.

    Conclusions:

    • Growth hormone is implicated in the complex processes of ocular development.
    • Further research is warranted to fully elucidate the mechanisms of GH action in the eye.
    • Understanding GH's role may lead to new insights into treating ocular development disorders.