Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomic imprinting effects on brain development and function.

Lawrence S Wilkinson1, William Davies, Anthony R Isles

  • 1Behavioural Genetics Group, School of Psychology and Department of Psychological Medicine, School of Medicine, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK. wilkinsonl@cardiff.ac.uk

Nature Reviews. Neuroscience
|October 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental defects revealed by modelling PWS in mice.

Disease models & mechanisms·2026
Same author

Synaptic and Circuit Mechanisms Shaping Neurodevelopmental and Psychiatric Outcomes Associated with 16p11.2 Copy Number Variation.

Genes·2026
Same author

A novel pupillometer smartphone application demonstrates accurate results compared with a validated clinical pupillometer: The Pupillary Light Response Validation (PLR-V) Study.

Anaesthesia and intensive care·2026
Same author

A mixed-methods online survey approach using retrospective self-reporting to characterise congenital ichthyoses across age groups.

Orphanet journal of rare diseases·2026
Same author

Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation.

Neuropharmacology·2026
Same author

Does hypothalamic CCN3 hypersecretion confer postpartum mood disorder risk?

Translational psychiatry·2026
Same journal

Rewarding experiences boost motor performance.

Nature reviews. Neuroscience·2026
Same journal

Driving neuronal apoptosis.

Nature reviews. Neuroscience·2026
Same journal

Using human 3D organoid models to gain mechanistic insight in motor neuron diseases.

Nature reviews. Neuroscience·2026
Same journal

What scrub jays have taught us about the neural intersection of memory and action selection.

Nature reviews. Neuroscience·2026
Same journal

Boundary issues for multidimensional frameworks of representation.

Nature reviews. Neuroscience·2026
Same journal

Reply to 'Boundary issues for multidimensional frameworks of representation'.

Nature reviews. Neuroscience·2026
See all related articles

Imprinted genes, a small fraction of mammalian genes, are silenced based on parental origin. These genes significantly impact brain development, function, and behavior, posing an evolutionary puzzle.

Area of Science:

  • Genetics
  • Developmental Biology
  • Neuroscience

Background:

  • A small subset of mammalian genes, less than 1%, exhibit parent-specific silencing.
  • This phenomenon, known as genomic imprinting, determines which inherited allele is active.
  • Imprinted genes challenge the typical advantages of diploidy in inheritance.

Purpose of the Study:

  • To investigate the role and implications of imprinted genes.
  • To understand their influence on mammalian physiology and behavior.
  • To explore their specific impact on neurodevelopmental processes and brain function.

Main Methods:

  • Analysis of gene expression patterns in mammals.
  • Investigating parent-of-origin effects on allele silencing.
  • Reviewing evidence linking imprinted genes to neurodevelopment.

Related Experiment Videos

Main Results:

  • Imprinted genes are crucial for normal physiology and behavior.
  • A significant number of imprinted genes are expressed in the brain.
  • Evidence suggests their influence on neurodevelopmental pathways.

Conclusions:

  • Genomic imprinting is an evolutionary enigma with significant biological consequences.
  • Imprinted genes play a critical role in brain development and function.
  • Further research is needed to fully understand their impact on behavior.