[The effect of different chemoembolization materials on CT-based attenuation correction in PET/CT]
T-A Heusner1, U Fronz, W Jentzen
1Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Universitätsklinik Essen, Essen. till.heusner@uni-due.de
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|October 11, 2007
Summary
Chemoembolization materials used in PET/CT scans can falsely inflate tracer uptake measurements. This study quantifies the overestimation caused by different agents, crucial for accurate liver tumor follow-up imaging.
Area of Science:
- Nuclear medicine
- Radiology
- Oncology
Background:
- Transarterial chemoembolization (TACE) is used for liver tumors.
- Accurate PET/CT imaging is vital for treatment monitoring.
- Chemoembolization materials may interfere with PET attenuation correction.
Purpose of the Study:
- To experimentally quantify the impact of various chemoembolization materials on PET activity concentration.
- To assess the overestimation of PET activity caused by different agents in PET/CT.
Main Methods:
- A liver phantom was used with different chemoembolization materials (lipiodol, tungsten, tantalum, platinum coils).
- PET/CT scans were performed with [18-F]-Fluor-2-deoxy-D-glucose (FDG).
- PET attenuation correction was based on CT data, and activity concentration overestimation was calculated.
Main Results:
- All tested chemoembolization materials caused an overestimation of PET activity concentration.
- The degree of overestimation varied significantly, ranging from 4-29% for platinum coils to 34-1827% for tungsten.
- Overestimation was dependent on the concentration and density of the embolizing agent.
Conclusions:
- Conventional chemoembolization materials lead to significant overestimation of PET activity in CT-based attenuation-corrected PET/CT.
- Activity quantification for imaging follow-up may be unreliable with these agents.
- Non-attenuating materials or assessment of non-attenuation-corrected images are recommended to avoid artifacts.
More Related Videos
Related Concept Videos
01:28Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...