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Updated: Jul 11, 2026
08:07
A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
Published on: January 11, 2018
Changes in mechanical properties of bone within the mandibular condyle with age
Sarandeep S Huja1, Andrew M Rummel, Frank M Beck
1Section of Orthodontics, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA. huja.1@osu.edu
Journal of Morphology
|October 11, 2007
Summary
Adult dogs exhibit significantly higher indentation modulus and hardness in condylar bone compared to young dogs, indicating age-related changes in bone mass and material properties.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Comparative Anatomy
Background:
- The mandibular condyle's mechanical properties are crucial for jaw function.
- Understanding age-related changes in bone is vital for treating skeletal disorders.
Purpose of the Study:
- To compare indentation modulus (IM) and hardness of condylar bone in young and adult dogs.
- To evaluate bone formation activity in canine mandibular condyles across different age groups.
Main Methods:
- Mechanical testing of trabecular bone from young and adult dog mandibular condyles.
- Histomorphometric analysis to assess bone volume and bone formation rates.
- Utilized a custom hydration system for accurate indentation modulus and hardness measurements.
Main Results:
- Adult condylar bone showed significantly higher IM (10.0 GPa) than young condylar bone (5.6 GPa).
- Young condyles had greater bone mass (60.2%) compared to adult condyles (42%).
- Higher bone formation activity was observed in young dogs (66.1% labeled bone) versus adult dogs (27.5%).
Conclusions:
- Canine mandibular condylar bone undergoes significant changes in mass and material properties with age.
- Age influences both the structural integrity and the bone remodeling activity within the mandibular condyle.
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