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Updated: Jul 11, 2026
08:24
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
[Intestinal microbiocenosis in systemic connective tissue diseases]
Klinicheskaia Meditsina
|October 12, 2007
Summary
Systemic connective tissue diseases and vasculitis disrupt gut bacteria, decreasing beneficial anaerobes like lactobacilli and bifidobacteria while increasing harmful bacteria. This dysbiosis may inform new therapeutic strategies.
Area of Science:
- Microbiology
- Rheumatology
- Gastroenterology
Context:
- Systemic connective tissue diseases (SCTD) and systemic vasculitis are autoimmune conditions impacting multiple organs.
- Alterations in the gut microbiome are increasingly recognized as potential contributors to autoimmune diseases.
Purpose:
- To investigate the quantitative and qualitative changes in colon microflora composition in patients with SCTD and systemic vasculitis.
- To determine the symbiotic interrelations among microorganisms within the colon microbiocenosis of these patients.
Summary:
- Colon microflora in patients with systemic lupus erythematosus, systemic scleroderma, nodular polyarteritis, and hemorrhagic vasculitis exhibited significant dysbiosis.
- A decrease in anaerobic microorganisms, particularly lactobacilli, bifidobacteria, and bacteroides, was observed.
- There was a notable increase in conditionally pathogenic bacteria, including staphylococci and enterobacteria, some with hemolytic activity.
Impact:
- Identified specific trends in colon microflora alterations associated with rheumatic diseases.
- Findings provide a basis for developing complex therapeutic approaches, including the correction of dysbiotic disturbances in these patient populations.
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