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Updated: Jul 11, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
[Clinical features of NSAID-induced small intestinal damage]
Satoshi Sugimori1, Toshio Watanabe, Masatsugu Shiba
1Department of Gastroenterology, Osaka City University Graduate School of Medicine.
Abstract:
Various factors have been shown to be involved in the pathophysiology of NSAID-induced small intestinal damage. Recent advances in diagnostic methods including video capsule endoscopy and double-balloon endoscopy have enabled us to examine the entire small intestine, and we now recognize that prevalence of small intestinal damage in patients taking NSAIDs is high. NSAIDs cause intestinal damage including redness, erosions, and ulcers in both jejunum and ileum. Most of patients with intestinal pathology are asymptomatic, although a few patients present with iron deficiency anemia and/or hypoalbuminaemia. The risk factors for NSAID-induced enteropathy are unknown. Experimental and clinical studies would unravel the mechanism by which NSAIDs injure intestinal mucosa.
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