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Updated: Jul 11, 2026
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture
Published on: December 22, 2016
[Effects of acupuncture at "Sishencong" (EX-HN 1) on physiological functions in the sleep disorder model mouse]
Xi-yan Gao1, Qiao-lin Ma, Bin Hu
1School of Acupuncture & Massage, Henan College of TCM, Zhengzhou 450008, China.
Objective:
To probe into the effect of acupuncture at "Sishencong" (EX-HN 1) on sleep and the mechanism.
Methods:
Forty-eight white mice were randomly divided into a Sishencong group, a Zusanli group, a model group and a blank control group, 12 mice in each group. In the mice of the first 3 groups, sleep rhythm disorders was induced by repeatedly regular intraperitoneal injection of small dose of Caffeine, and the mice of the first two groups were treated by acupuncture at "Sishencong" (EX-HN 1) and "Zusanli" (ST 36), respectively. Living state and, circadian activities were observed, and nitric oxide synthase (NOS) activity and nitric oxide(NO) content in the brain were detected.
Results:
Acupuncture at "Sishencong" (EX-HN 1) or "Zusanli" (ST 36) could significantly increase NOS activity and NO content in the brain, with acupuncture at "Sishencong" (EX-HN 1) being significantly better than acupuncture at "Zusanli" (ST 36) (P < 0.01).
Conclusion:
Acupuncture at Sishencong (EX-HN 1) treats insomnia and regulates sleep and many mental and nervous symptoms, which are carried out partially through increasing NOS activity and NO content, promoting normal function of brain tissues.
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