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Updated: Jul 11, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
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Published on: February 9, 2021

Primary hyperoxaluria.

Patou Tantbirojn1, Wipawee Kittikowit, Pornchai Kingwattanakul

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Bangkok 10330, Thailand. two_devil@hotmail.com

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|October 12, 2007
PubMed
Summary

This case study highlights a rare infant case of acute renal failure due to primary hyperoxaluria, emphasizing diagnostic challenges and the critical need for early detection of this severe condition.

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Published on: June 20, 2018

Area of Science:

  • Pediatric Nephrology
  • Medical Genetics
  • Clinical Pathology

Background:

  • Primary hyperoxaluria is a rare inherited metabolic disorder.
  • It leads to excessive oxalate production and deposition in kidneys, causing renal failure.
  • This case presents a diagnostic challenge in an infant with atypical symptoms.

Observation:

  • A 5-month-old infant presented with chronic diarrhea and acute renal failure.
  • Investigations revealed hyperoxaluria, hypocalcemia, hyperphosphatemia, and oxalosis maculopathy.
  • Kidney biopsy confirmed diffuse oxalate crystal deposition.

Findings:

  • The infant's acute renal failure was attributed to primary hyperoxaluria.
  • Diagnosis was challenging due to atypical presentation and limited diagnostic facilities in Thailand.
  • The patient expired despite continuous venovenous hemodiafiltration.

Implications:

  • This case highlights the importance of early diagnosis of primary hyperoxaluria, even with unusual presentations.
  • It underscores the need for accessible diagnostic tools for rare diseases in resource-limited settings.
  • Timely intervention is critical for managing hyperoxaluric nephropathy and improving patient outcomes.