Related Experiment Video
Updated: Jul 11, 2026

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
Published on: September 16, 2013
Expanding role of lipid II as a target for lantibiotics
Nathaniel I Martin1, Eefjan Breukink
1Utrecht University, Department of Medicinal Chemistry & Chemical Biology, 3584 CA Utrecht, The Netherlands. n.i.martin@uu.nl
Abstract:
Lipid II is an essential cell-wall precursor required for the growth and replication of both Gram-positive and Gram-negative bacteria. Compounds that use lipid II to selectively target bacterial cells for destruction represent an important class of antibiotics. Clinically, vancomycin is the most important example of an antibiotic that operates in this manner. Despite being considered the 'antibiotic drug of last resort', significant bacterial resistance to vancomycin now manifests itself worldwide. In this paper we review recent progress made in understanding the lipid II-associated antibacterial characteristics of various naturally occurring compounds, with particular focus on the lantibiotic peptides.
More Related Videos
10:59Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
10:58Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
Published on: March 29, 2017
Related Concept Videos
Formation of Lipopolysaccharides
Biosynthesis of Lipids
Inhibitors of Gram-positive Cell Wall Synthesis
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Clinical Significance of Antibiotic Resistance