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Concomitant Creutzfeldt-Jakob and Alzheimer diseases
1Department of Pathology, Columbia-Presbyterian Medical Center, New York, NY.
Acta Neuropathologica
|January 1, 1991
Abstract:
We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.