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Updated: Jul 11, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Individualized compared with conventional dosing of enoxaparin
M A Barras1, S B Duffull, J J Atherton
1School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia.
Clinical Pharmacology and Therapeutics
|October 12, 2007
Summary
Individualized enoxaparin dosing significantly reduced bleeding and bruising events compared to conventional methods. This optimized regimen improved patient safety without compromising treatment effectiveness in preventing thromboembolic events.
Area of Science:
- Pharmacology
- Clinical Medicine
- Drug Dosing
Background:
- Enoxaparin is a widely used anticoagulant.
- Current enoxaparin dosing practices may lead to suboptimal outcomes.
- Individualized dosing strategies are being explored to improve safety and efficacy.
Purpose of the Study:
- To compare an individualized enoxaparin dosing regimen with conventional dosing.
- To assess the impact of individualized dosing on bleeding events and treatment effectiveness.
Main Methods:
- Patients were assigned to either an individualized or conventional enoxaparin dosing group.
- Individualized dosing considered total body weight (<100 kg) or lean body weight (>=100 kg), with adjustments based on renal function at 48 hours.
- Conventional dosing followed standard clinical practice.
Main Results:
- The individualized enoxaparin group experienced significantly fewer bleeding events (RR=0.12, P=0.03) and composite bleeding/bruising events (RR=0.30, P=0.003) compared to the conventional group.
- No recurrent thromboembolic events or 30-day deaths were observed in either group, indicating preserved effectiveness.
Conclusions:
- Individualized enoxaparin dosing is effective in reducing bleeding and bruising.
- This optimized dosing approach enhances patient safety without compromising the anticoagulant's efficacy.
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