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FTO polymorphisms in oceanic populations.

Jun Ohashi¹, Izumi Naka², Ryosuke Kimura³

¹Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. juno-tky@umin.ac.jp.

Journal of Human Genetics

|October 12, 2007

Summary

This summary is machine-generated.

The "thrifty genotype" hypothesis may not explain obesity in Oceanic populations. Common fat mass and obesity (FTO) gene variants showed no association with body mass index (BMI) in this study.

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Area of Science:

Genetics
Anthropology
Obesity Research

Background:

The "thrifty genotype" hypothesis proposes that certain gene variants promote obesity, particularly in populations experiencing rapid environmental change.
Common variants in the fat mass and obesity (FTO) gene are linked to body mass index (BMI) and obesity in European populations.

Purpose of the Study:

To investigate the population frequencies of specific FTO gene variants (rs1421085-C, rs17817449-G, rs9939609-A) in six Oceanic populations.
To test for an association between these FTO polymorphisms and BMI in Melanesians, Micronesians, and Polynesians.

Main Methods:

Genotyping of common FTO variants (rs1421085-C, rs17817449-G, rs9939609-A) in individuals from six Oceanic populations.
Statistical analysis to determine the association between FTO variant frequencies and Body Mass Index (BMI).
Assessment of linkage disequilibrium among the studied FTO variants.

Main Results:

The investigated FTO polymorphisms were found in 4.2–30.3% of the Oceanic populations studied.
No significant association was observed between the FTO polymorphisms and BMI in the Oceanic populations, contrasting with findings in European populations.
The studied FTO variants were in strong linkage disequilibrium and showed frequencies similar to those in Southeast and East Asian populations.

Conclusions:

The study found no evidence to support the "thrifty genotype" hypothesis as an explanation for high body weights in Oceanic populations based on the investigated FTO gene variants.
The genetic architecture of obesity in Oceanic populations may differ from that in European populations, suggesting alternative genetic or environmental factors.
Frequencies of these FTO variants in Oceanic populations resemble those in Asian populations, indicating potential shared genetic history or migration patterns.