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Altered States of Awareness01:06

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain that...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
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Related Experiment Video

Updated: Jul 11, 2026

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
04:44

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Published on: February 16, 2024

[Khat-induced psychosis?].

G Degraeve1

  • 1gunther.degraeve@fracarita.org

Tijdschrift Voor Psychiatrie
|October 12, 2007
PubMed
Summary

Khat, a stimulant with amphetamine-like effects, may trigger psychosis in susceptible individuals. Discontinuing khat use, potentially with antipsychotics, is the recommended treatment for suspected khat-induced psychosis.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Khat (Catha edulis) is a stimulant drug widely used in East Africa and the Arabian Peninsula.
  • Its primary psychoactive components, cathinone and cathine, exhibit amphetamine-like stimulant properties.
  • The potential for khat to induce psychosis remains a subject of debate within the scientific literature.

Observation:

  • This report details two distinct cases of individuals experiencing psychosis potentially linked to khat consumption.
  • Both cases involved users with a history of significant khat intake.
  • Clinical presentation included symptoms consistent with acute psychotic episodes.

Findings:

  • The presented cases suggest a possible etiological link between khat use and the onset of psychotic symptoms.

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Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
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  • While definitive causality is difficult to establish, the temporal association and symptomology are noteworthy.
  • No consensus exists, but these cases add to the body of evidence suggesting khat as a potential psychosis-inducing agent.
  • Implications:

    • These findings underscore the importance of considering khat use in the differential diagnosis of psychosis, particularly in endemic regions.
    • Discontinuation of khat consumption emerged as a primary therapeutic strategy in both cases.
    • Adjunctive treatment with antipsychotic medications may be beneficial for managing acute symptoms of suspected khat-induced psychosis.