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Updated: Jul 11, 2026
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Clinical efficiency and safety analysis of transcatheter interventional therapy for compound congenital
Zhi-Yuan Song1, Mao-Qin Shu, Hou-Yuan Hu
1Department of Cardiology, Southwest Hospital, The Third Military Medical University, Chongqing, China. zysong@public.cta.cq.cn
Insights
Transcatheter interventional therapy effectively treats complex congenital heart defects. This minimally invasive approach demonstrated high success rates and safety in a study of 36 patients.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Compound congenital cardiovascular abnormalities present complex therapeutic challenges.
- Transcatheter interventional therapy offers a less invasive alternative to surgical repair.
Purpose of the Study:
- To evaluate the safety and efficacy of transcatheter interventional therapy for patients with multiple congenital heart defects.
- To assess the feasibility of a staged interventional approach based on defect complexity.
Main Methods:
- A cohort of 36 patients with various combined congenital heart defects underwent transcatheter procedures between 2001 and 2006.
- Procedures included balloon valvuloplasty for stenosis and device closure for septal defects and patent ductus arteriosus.
- Patients were monitored with electrocardiogram and echocardiogram post-procedure.
Main Results:
- Transcatheter interventions were successful in all 36 patients.
- Specific procedures included device implantation for septal defects and patent ductus arteriosus, and balloon valvuloplasty for pulmonary and mitral stenosis.
- No serious adverse events were reported during a mean follow-up of 30.5 months.
Conclusions:
- Transcatheter interventional therapy is a technically feasible and effective treatment for compound congenital cardiovascular abnormalities.
- The approach yields satisfactory clinical outcomes, supporting its use in complex pediatric cardiac cases.
Objective:
To investigate the efficiency and safety of transcatheter interventional therapy for compound congenital cardiovascular abnormalities.
Methods:
From Nov 2001 to Jun 2006, a total of 36 patients (17 male, 19 female), aged 17.20 +/- 10.52, with compound congenital cardiovascular abnormalities underwent transcatheter interventional procedure. These patients included 11 with perimembranous ventricular septal defect (PVSD) and patent ductus arteriosus (PDA), 8 patients with PVSD and atrial septal defect (ASD), 8 patients with ASD and PDA, 7 patients with ASD and pulmonary stenosis (PS), 1 patient with ASD and mitral stenosis(MS), 1 patient with coarctation of aorta (COA) and PDA. According to the principle of "easy first, hard second," balloon valvuloplasties of PS or MS were performed before the closure of PVSD, and of PDA and ASD. Electrocardiogram and transthoracic echocardiogram were examined at 4 days, 1, 2, 6 and 12 months, respectively, after each procedure.
Results:
Transcatheter interventional therapy for compound congenital cardiovascular abnormalities was successful in all patients. Among these, 2 occluders were planted in each of 27 patients, 7 patients with ASD combined with PS and 1 patient with ASD combined with MS underwent successfully performed balloon valvuloplasty and ASD closure, 1 patient with COA combined with PDA underwent successfully performed balloon valvuloplasty and subsequent covered stent implantation. No patient encountered serious adverse events during the (30.5 +/- 14.6) months of follow-up.
Conclusions:
Transcatheter interventional therapy for compound congenital cardiovascular abnormalities could obtain satisfactory results with technical feasibility.
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