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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Phototriggers for nucleobases with improved photochemical properties
Toshiaki Furuta1, Takayoshi Watanabe, Satoshi Tanabe
1Department of Biomolecular Science and Research Center for Materials with Integrated Properties, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp
Abstract:
Synthesis and photochemical properties of new photoremovable protecting groups for nucleobases are described. Four caged 2'-deoxycytidines (dCs) were synthesized, and their photochemical properties were measured under simulated physiological conditions. Two new coumarin-caged dCs show better photochemical and photophysical properties than those of the caged dCs having previously reported caging groups.
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