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Updated: Jul 11, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Lanthanide-containing polymer nanoparticles for biological tagging applications: nonspecific endocytosis and cell
Cédric Vancaeyzeele1, Olga Ornatsky, Vladimir Baranov
1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada.
Abstract:
We describe the synthesis and characterization of element-encoded polystyrene nanoparticles with diameters on the order of 100 nm and a narrow size distribution. Individual particles contain ca. 10(3) chelated lanthanide ions, of either a single element or a mixture of elements. These particles were effectively internalized by nonspecific endocytosis into three cell lines associated with human leukemia. Using an assay based upon ICP-MS detection, we could monitor quantitatively cell adhesion induced by cell differentiation of THP-1 cells in response to phorbol ester stimulation (PMA) in single cell type or mixed cultures.

