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Updated: Jul 11, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Construction of three contiguous tertiary stereocenters from aziridines in one step
Evgeniy V Blyumin1, Helen J Gallon, Andrei K Yudin
1Davenport Research Labs, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada.
Abstract:
A range of active methylene nucleophiles were found to participate in ring-opening of tosylated aziridines under mild phase-transfer catalyzed conditions. High isolated yields coupled with a 1:1 reaction stoichiometry and high levels of relative stereocontrol are distinguishing features of this method. The products are obtained without epimerization, underscoring the optimal conditions afforded by the phase-transfer catalysis for connecting active methylene nucleophiles and weakly electrophilic N-tosylated aziridines.
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