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Transient inhibition of murine progressive ankylosis by indomethacin
1Department of Medicine, Minneapolis VA Medical Center, MN 55417.
Abstract:
Murine progressive ankylosis (MPA) is an heritable disorder which produces acute arthritis and ankylosis of peripheral and axial joints similar to ankylosing spondylitis. Because indomethacin inhibits heterotopic bone formation in vivo, we studied its effects on MPA. Indomethacin was administered for 6 weeks beginning at weaning to litters from heterozygote breeder pairs. Progression curves for peripheral, spinal and thoracic joint ankylosis in treated and untreated ank/ank animals wer compared. There was no delay in ankylosis of peripheral or spinal joint ankylosis in MPA animals treated with indomethacin. interestingly, transient delay of thoracic ankylosis occurred in indomethacin treated MPA animals.
Insights
Indomethacin did not prevent joint ankylosis in murine progressive ankylosis (MPA) models. However, it did cause a temporary delay in thoracic joint ankylosis in these arthritis models.
Area of Science:
- Genetics and Musculoskeletal Disorders
- Pharmacology and Drug Efficacy
Background:
- Murine progressive ankylosis (MPA) is a genetic disorder causing arthritis and joint fusion, resembling human ankylosing spondylitis.
- Indomethacin is known to inhibit heterotopic bone formation.
Purpose of the Study:
- To investigate the effects of indomethacin on the progression of joint ankylosis in a murine model of progressive ankylosis.
Main Methods:
- Indomethacin was administered to young mice from heterozygote breeder pairs for six weeks.
- Progression of peripheral, spinal, and thoracic joint ankylosis was compared between treated and untreated MPA animals.
Main Results:
- Indomethacin treatment did not delay peripheral or spinal joint ankylosis in MPA mice.
- A transient delay in thoracic joint ankylosis was observed in indomethacin-treated MPA mice.
Conclusions:
- Indomethacin is ineffective in preventing generalized joint ankylosis in MPA.
- Indomethacin may have a specific, albeit temporary, effect on thoracic joint fusion in this model.