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Advances in management of paranasal sinus aspergillosis

A Daudia1, N S Jones

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

The Journal of Laryngology and Otology
|October 13, 2007
PubMed

Insights

Surgery is primary for paranasal sinus mycetoma. Itraconazole aids in allergic aspergillosis management by reducing surgery and bleeding, potentially lowering recurrence. It may cure chronic invasive aspergillosis.

Area of Science:

  • Medical Mycology
  • Otolaryngology
  • Infectious Diseases

Background:

  • Mycetoma of the paranasal sinuses requires effective management strategies.
  • Aspergillosis, a fungal infection, presents in various forms affecting the sinuses.

Purpose of the Study:

  • To review the management of fungal sinusitis, specifically aspergillosis.
  • To evaluate the role of itraconazole in treating paranasal sinus aspergillosis.

Main Methods:

  • Review of existing literature on paranasal sinus aspergillosis management.
  • Analysis of itraconazole's efficacy in different forms of fungal sinusitis.

Main Results:

  • Surgery is the mainstay for mycetoma.
  • Itraconazole reduces surgical needs and bleeding in allergic aspergillosis and may cure chronic invasive forms.
  • Radical surgery and amphotericin B remain key for fulminant aspergillosis.

Conclusions:

  • Itraconazole plays a significant role in managing allergic and chronic invasive aspergillosis of the paranasal sinuses.
  • Post-operative itraconazole may reduce recurrence rates in allergic aspergillosis.
  • Monitoring liver function and drug interactions is crucial when using itraconazole.

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