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Protein adsorption and platelet adhesion onto ion-containing polyurethanes
Sara Alibeik1, Heather Sheardown, Amin S Rizkalla
1Biomedical Engineering Graduate Program, University of Western Ontario, London, ON, Canada N6A 5B9.
Journal of Biomaterials Science. Polymer Edition
|October 13, 2007
Summary
Incorporating ions into polyurethane biomaterials increases protein adsorption and platelet adhesion. Ion location impacts fibrinogen adsorption but not platelet adhesion, suggesting limited benefit for blood compatibility.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biocompatibility
Background:
- Polyurethane biomaterials are crucial for blood-contacting devices.
- The influence of ionic groups on biomaterial blood response is not fully understood.
- Understanding protein adsorption and platelet adhesion is key to improving hemocompatibility.
Purpose of the Study:
- To investigate the effect of ion incorporation on protein adsorption and platelet adhesion in polyurethanes.
- To determine if the location of ions (soft vs. hard segments) influences these blood-contacting properties.
- To clarify the role of ionic groups in the hemocompatibility of polyurethane biomaterials.
Main Methods:
- Synthesis of ion-containing polyurethanes with ions in soft or hard segments.
- In vitro assessment of protein adsorption (albumin, lysozyme, fibrinogen).
- In vitro evaluation of platelet adhesion.
Main Results:
- Ion-containing polyurethanes showed increased protein adsorption and platelet adhesion.
- Fibrinogen adsorption was significantly dependent on ion location, unlike albumin and lysozyme.
- Platelet adhesion showed less dependence on ion location within the polyurethane structure.
- Ion incorporation alone did not improve blood compatibility without biocompatible chains like polyethyleneoxide.
Conclusions:
- The study unequivocally demonstrates the role of ions in protein adsorption and platelet adhesion on polyurethanes.
- Ion location influences specific protein adsorption (fibrinogen) but not overall platelet adhesion.
- Ion incorporation into polyurethanes may not be a suitable strategy for enhancing blood compatibility in medical devices without other modifications.
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