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Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
Published on: March 27, 2018
The cannabinoid CB1 receptor is expressed on serotonergic and dopaminergic neurons
Thorsten Lau1, Patrick Schloss
1Biochemical Laboratory, Central Institute of Mental Health, J5, 68159 Mannheim, Germany.
Abstract:
The endocannabinoid system is involved in memory, cognition, and pain perception by the presynaptic cannabinoid CB(1) receptor, which is expressed at high levels in many brain regions. Functional studies have shown that activation of cannabinoid CB(1) receptors inhibits the synaptic release of many neurotransmitters such as gamma-aminobutyric acid, glutamate, acetylcholine and monoamines. Monoamines, however, are known not only to be released from and taken back up at nerve terminals but also at extrasynaptic axonal and somatodendritic sites. Here we present immunocytochemical data documenting cannabinoid CB(1) receptor expression on neurite extensions and over cell bodies of serotonergic and dopaminergic neurons.
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