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Updated: Jul 10, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Selection of solubility parameters for characterization of pharmaceutical excipients
Katarzyna Adamska1, Adam Voelkel, Károly Héberger
1Poznań University of Technology, Institute of Chemical Technology and Engineering, Pl. M. Skłodowskiej-Curie 2, 60-965 Poznań, Poland. Katarzyna.Adamska@put.poznan.pl
Abstract:
The solubility parameter (delta(2)), corrected solubility parameter (delta(T)) and its components (delta(d), delta(p), delta(h)) were determined for series of pharmaceutical excipients by using inverse gas chromatography (IGC). Principal component analysis (PCA) was applied for the selection of the solubility parameters which assure the complete characterization of examined materials. Application of PCA suggests that complete description of examined materials is achieved with four solubility parameters, i.e. delta(2) and Hansen solubility parameters (delta(d), delta(p), delta(h)). Selection of the excipients through PCA of their solubility parameters data can be used for prediction of their behavior in a multi-component system, e.g. for selection of the best materials to form stable pharmaceutical liquid mixtures or stable coating formulation.
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